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Chemical compound developed for curing Alzheimer's disease

A team of researchers from two Japanese universities and a science think tank has developed for the first time in the world a chemical compound which prevents the formation in the brain of the protein that causes Alzheimer's disease. The effectiveness of the substance was substantiated in an experiment using the brain of a mouse. Never before has the effectiveness of the substance been confirmed in a mouse experiment. The team comprised the Kyoto Pharmaceutical University's Professor Yoshiaki Kiso and researchers from the University of Tokyo and RIKEN.
Alzheimer's disease is believed to be caused by the accumulation of amyloid beta peptide (A B peptide), a type of protein. The chemical compound developed by Prof. Kiso's team is called KMI-429. It deters the workings of B secretarze which is related to the formation of AB peptide. When the compound was injected into the brain of a mouse, the formation of AB peptide was reduced by 30-40% in three hours. No side effects were noticed.
The achievement was reported at a symposium held recently in Osaka by the Pharmaceutical Society of Japan.
For inquiries, please contact Department of Medicinal Chemistry, Kyoto Pharmaceutical University (Tel:075-595-4635) URL http://www.kyoto-phu.ac.jp/labo/yakuhin/