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Mechanism of the HIV Multiplication Clarified

 Prof. Akifumi Takaori and his research team from Kyoto University have found a new mechanism that promotes the multiplication of AIDS viruses (HIV). This achievement has been listed in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) (online version).
 When infecting, HIV multiplies by replicating its own genes. The finding of this research is that when HIV infects a cell, a protein called “Vif” acts on a protein called “p53”, which affects the control of the cell cycle, and stops the division cycle of the infected cell at the state that is best for viral replication. When the division cycle is stopped in this state, the rate of multiplication is enhanced as much as 100 times.
 While the past research findings have already revealed that Vif accelerates viral multiplication by decomposing a protein called “APOBEC 3G”, which hinders viral replication, this research has revealed that Vif stimulates the viral multiplication even in different mechanisms.
 The research team anticipates that by clarifying various mechanisms of Vif that cause the HIV viral multiplication, new drug development targeting Vif will be promoted.
 
 
Contact : Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine
Phone or E-mail 075-751-3150
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